Soarawee Weerasopone, Urologist
Samitivej Sriracha hospital, Thailand
Burapha University hospital, Thailand
Royal Phnom Penh hospital, Cambodia
VDRL test or Venereal Disease Research Laboratory test is a very common syphilis screening test which physicians currently using for all over the world. Due to an easily accessible even the patients themselves can find this either test at local laboratory nearby their home without consulting with experts before drawing blood sampling from their vein. The problem will be occurred when VDRL turn positive without any suspicious of syphilis infection, we called this incident “Biological false positive” or BFP reaction. With this thing the result seems to be horrifying the patients by an affecting their mentally and daily performance. Today we will discuss on this BFP phenomenon.
BFP phenomenon has been reported around 1 – 2 % of an incidence. BFP usually showing out in a low dilutions (<1:8) and here are the possibilities of BFP phenomenon.
Causes of VDRL False positive phenomenon.
- The reliability of laboratory you get tested
- A wrong interpretation from unwell-trained technicians is the first thing we must consider or suspect.
- Presenting of autoimmune diseases
- SLE or Systemic Lupus Erythematous
- Rheumatoid arthritis
- Febrile illness
- Malaria
- Tuberculosis
- Filariasis
- Pregnancy
- Recent immunization
- Aging
- Drug addiction
- Liver disease
- Malignancy
Once BFP phenomenon is suspected, a very carefully history taking, and the proper investigation must be done for any clarifying on what is the real cause of BFP phenomenon. It would be recommended to retest VDRL again at 10 weeks which is the most cases will turn nonreactive at the period of time. Any questions, you can discuss with your trusted physicians, or it would be my honor if you can text me. Take care!
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